Arrayit InnoScan® MAPIX® Microarray Scanner Software

Price: $5,367.00

Item Number: MAPIX

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Arrayit InnoScan® MAPIX® Microarray Scanner Software including scanner controller software that offers complete instrument control including scanner gain, laser, and speed settings, autoloader control, TIFF and JPEG data file outputs, as well as quantification and data analysis capabilities that include a full range of statistical parameters such as automatic spot finding and grid alignment, spot exclusion, signal-to-noise, 532 nm and 635 nm channel outputs, signal, background, noise and GenePix Arrayit List (GAL) inputs. MAPIX® works in conjunction with all Arrayit InnoScan® Microarray Scanners including 710, 910 and 1100 series instruments, one seat per license.

Microarray Scanners - Arrayit InnoScan® 710, 710AL, 710IR, 710IRAL, 910, 910AL and 1100AL High Speed Fluorescence Microarray Scanners

InnoScan.2
Arrayit InnoScan® 710, 910, 910AL and 1100AL high-performance microarray scanners comprise the newest instruments in our laser scanning series. These compact, desktop instruments feature proprietary rotary motion control for superior speed and durability, complete controller and Mapix® quantification and data analysis software, dynamic auto-focusing for superior precision, and two-color (710, 710AL, 910 and 910AL) and three-color (1100AL) detection. The Arrayit InnoScan® 710 and 710AL are next generation microarray scanners with greater sensitivity and lower background, proprietary rotary motion control, dynamic auto-focusing, 2-color fluorescence detection, 3 µm scan resolution, 3 minute scan times and complete software. The Arrayit InnoScan® infrared 710IR and 710IRAL enable infrared microarray detection. The Arrayit InnoScan® 1100AL is our top-of-the-line scanner featuring 488 nm (FITC), 532 nm (cyanine 3) and 635 nm (cyanine 5) three-color scanning and a world’s best 0.5 µm scan resolution for microarray and tissue microarray applications in research and clinical laboratories leveraging genomics, proteomics, molecular testing and pharmaceutical drug discovery.

Arrayit-910AL
Figure 1. Arrayit InnoScan 910, 910AL and 1100AL Microarray Scanners are ideal for low- and medium-density two-color DNA microarrays for comparative gene expression analysis of test and control samples. Two-color microarrays offer the market’s most rapid and affordable means of identifying genes involved in human disease onset and progression, drug mode of action and many other pathways.

Arrayit 1100AL
Figure 2. Arrayit InnoScan 910, 910AL and 1100AL Microarray Scanners support a wide variety of 1 x 25 x 76 mm glass substrate slides including silane-activated glass, nitrocellulose-coated glass and slides with other membranes, SuperMask and other microarray dividers, and popular formats from major suppliers including Arrayit, Agilent and Schott.

Figure 3. Arrayit InnoScan 910, 910AL and 1100AL Microarray Scanners support the growing protein microarray industry including antigen, antibody, peptide, and reverse phase cell lysate microarrays for protein expression assays, protein binding studies, drug discovery, serum-based immunoassays and many others.

innoscan-1100
Figure 4. Arrayit InnoScan 910, 910AL and 1100AL Microarray Scanners empower high-density DNA and protein microarray analysis including chips with hundreds of thousands to millions of individual features. The 910 and 910AL and the 1100AL instruments utilize 1.0 µm and 0.5 µm scan resolution, respectively, to rapidly interrogate the human genome and proteome in a highly accurate and cost-effective manner.

Arrayit InnoScan 910 910AL
Figure 5. Arrayit InnoScan 910 and 910AL high-speed microarray scanners offer two-color 532 nm and 635 nm detection, 1 µm scan resolution and single substrate slide (910) and 24-slide autoloader (910AL) for exceptional performance and ease-of-use in compact desktop scanners. All systems are equipped with a BioBlue Personal Computer, Mapix® quantification and analysis software, and complete cables and accessories for 30-minute setup time and years of reliable performance.

Table 1. Arrayit InnoScan® 910, 910AL and 1100AL Microarray Scanner Specifications.

Specification	Arrayit InnoScan® 910 and 910AL	Arrayit InnoScan® 1100AL
General Description	Characterized by simplicity of use, competitive price and superior image quality, Arrayit® InnoScan® 910 scanners are ideal instruments for scanning most high density microarrays available on the market. The single substrate slide (910) and 24-substrate slide autoloader (910AL) scanners feature high resolution 1 µm scanning, high speed 3.5 min per slide 10 µm scan time, reliable and traceable results with barcode reading, comprehensive Mapix image quantification and analysis software, and proprietary high-speed Arrayit BioBlue Computing to manage the 5.74 GB data files produced by 1 µm scanning.	Characterized by ease of use, performance and versatility, the Arrayit InnoScan 1100AL is an ideal instrument for high density DNA, protein, tissue and whole cell microarrays and one-, two- and three-color applications. The 24-substrate slide autoloader 1100AL features a market-leading 0.5 µm scan resolution equivalent to a 20x optical objective, high speed 3.5 min per slide 10 µm scan time, reliable and traceable results with barcode reading, real-time auto-focusing, confocal PMT detection, user-friendly Mapix image acquisition and analysis software, and proprietary high-speed Arrayit BioBlue Computing to manage the 22.96 GB data files produced by 0.5 µm scanning.
Applications	Arrayit InnoScan 910 and 910AL instruments are ideal for scanning most low-, medium- and high-density microarrays currently available on the market for genotyping, gene expression comparative genomic hybridization (CGH), copy number variation (CNV), DNA methylation, miRNA studies, carbohydrate microarrays, antigen and antibodiy microarrays, proteomics and many other appolications.	The Arrayit InnoScan 1100AL instrument is ideal for rapid and high-performance automated scanning of low-, medium- and high-density microarrays containing DNA, peptides, antibodies, microenvironment sensors, transfected cells, glycans and many other sample types for genotyping, gene expression, comparative genomic hybridization (CGH), copy number variation (CNV), DNA methylation, miRNA studies, biomarker identification, human diseaes analysis, tissue microarray (TMA), tissue immunofluorescence for one-, two- and three-color applications in research, life sciences, microarray testing, pharmaceuticals and other areas.
Technology	Arrayit InnoScan® 910 and 910AL instruments leverage confocal scanning, two lasers, two extremely sensitive analog photomultiplier tubes (PMT), and linear gain from 0.1-100%. Full PMT control makes it easy to adjust scanner sensitivity to read the complete range of microarray signal intensities. Real-time auto-focusing ensures scan uniformity across the entire substrate slide. Extended Dynamic Range (XDR) and 20-bit TIFF images enable dynamic range exceeding 1 x 10^6 and detection of the dimmest signals while avoiding saturation. The 910 and 910AL have excellent photometric properties, particularly in terms of sensitivity and signal-to-noise ratio.	The Arrayit InnoScan® 1100AL instrument leverages confocal scanning, three lasers, three extremely sensitive analog photomultiplier tubes (PMT), and linear gain from 1-100%. Full PMT control makes it easy to adjust scanner sensitivity to read the complete range of microarray signal intensities. Real-time auto-focusing ensures scan uniformity across the entire substrate slide. Extended Dynamic Range (XDR) and 20-bit TIFF images enable dynamic range exceeding 1 x 10^6 and detection of the dimmest signals while avoiding saturation. The 1100AL has excellent photometric properties, particularly in terms of sensitivity and signal-to-noise ratio.
Resolution	1-40 µm per pixel	0.5-40 µm per pixel
Excitation wavelength	532 nm and 635 nm	488 nm, 532 nm and 635nm
Compatible fluorophores	532 nm: Cy3, Alexa 546, Alexa 555 635 nm: Cy5, Alexa 647, Alexa 660	488 nm: Cy2, Alexa488, FITC 532 nm: Cy3, Alexa 546, Alexa 555, Sytox orange 635 nm: Cy5, Alexa 647, Alexa 660, Draq5
Microarray format	Standard glass substrate slide format 1 x 25 x 76 mm	Standard glass substrate slide format 1 x 25 x 76 mm
Maximal scan area	22 x 74 mm	22 x 74 mm
Focus	Automatic or manual	Automatic or manual
Detection	Analog PMT and true confocal detection	Analog PMT and true confocal detection
PMT gain	Linear from 0.1 to 100% Possible gain < 1% with 0.01 step	Linear from 1 to 100%
Scanning mode	Simultaneous or sequential	Simultaneous or sequential
Scanning speed	10 to 35 lines per second	10 to 35 lines per second
Scanning time	3.5 minutes to scan a whole slide at 10 µm per pixel resolution	3.5 minutes to scan a whole slide at 10 µm per pixel and 3 colors 10.5 minutes for an area of 22 x 22 mm at 1 µm per pixel and 3 colors
Dimensions	32 x 55 x 43 cm (12.6” x 21.7” x 16.9” for the 910 33 x 66 x 44 cm3 (13” x 26” x 17.3”) for the 910AL	33 x 66 x 44 cm3 (13” x 26” x 17.3”) for the 1100AL
Weight	28 Kg (62 lbs) for the 910 38 Kg (83.6 lbs) for the 910AL	39 Kg (85.8 lbs) for the 1100AL
Interface	Ethernet	Ethernet
Barcode scanner	Yes	Yes
Image analysis and processing software	Mapix®	Mapix®
Image file format	16-bit and 20-bit TIFF	16-bit and 20-bit TIFF
Autoloader	24-slide automated (910AL)	24-slide automated

Arrayit scanner
Figure 6. Arrayit InnoScan 910, 910AL and 1100AL Microarray Scanners feature compact benchtop designs to permit user-friendly operation in a wide range of laboratory environments including research facilities and cleanroom manufacturing and testing centers.

peptide-array
Figure 7. Arrayit InnoScan 1100AL Microarray Scanner data image for a high density peptide microarray containing 10 µm feature size, 16 µm spacing and 440,000 peptide features per square centimeter. Data courtesy Dr. Alexander Nesterov-Muller, Institute of Microstructure Technology (IMT), Eggenstein-Leopoldshafen, Germany.

710 Product description

Latest next generation microarray scanning technology
Fastest and most compact microarray scanners available
Proprietary rotary scanning architecture permits the fastest scanning speeds
3 minutes to scan an entire 25 x 76 mm substrate slide
Scan 24 substrate slides in 100 minutes using the 710AL
Adjustable scan resolution from 3 µm to 40 µm
Ideal for both in situ and ex situ microarrays
710 and 710AL detect 532 nm (cyanine 3) and 635 nm (cyanine 5)
710IR and 710IRAL detect 670 nm (cyanine 5.5) and 785 nm (infrared dye)
Compatible IR dyes: IRDye 800 RS (Li-Cor), DyLight 800 (Pierce) and Alexa Fluor 790 (Invitrogen)
Rotary scanning architecture reduces vibrational noise and increases image quality
Much greater reliability and longevity than conventional raster scanners
High resolution acquisition system: scans spot sizes down to 30 µm diameter
Real-time image acquisition for all microarray types including but not limited to in-situ high density glass slide microarrays, spotted microarrays of all kinds, tissue and cell microarrays
Low background noise and high sensitivity system
Uniform scanning across the entire microarray surface regardless of substrate type (glass, membrane and plastic)
Not sensitive to shocks, vibrations and slide deformation (portable)
Delivered with Mapix® software: an easy to use data acquisition and image analysis software including automatic spot recognition and powerful image analysis
Software for various OS environments (Linux, Windows )
Ethernet interface allows easy data sharing (scanner can be shared over network by several users)
Affordable price, low maintenance
Lightweight, robust structure makes it portable system
Small footprint for laboratory space saving
Weight: 15 kg

Image acquisition and quantification demo available upon request, email us at arrayit@arrayit.com.

Table 2. Arrayit InnoScan® 710, 710AL, 710IR and 710IRAL Microarray Scanner Specifications.

Lasers	Thermoelectrically cooled laser diodes with stabilized feedback output
Excitation wavelengths	532 and 635 nm (710 and 710AL); 670 and 785 nm (710IR and 710IRAL)
Laser power	Adjustable (2 laser power settings available)
Gain PMT	Linear from 0 to 100%
Autofocus	Real-time and automated
Detection	True confocal and high performances digital laser/PMT system
Optical resolution	3 µm
Pixel size	3 µm to 40 µm
Scanning time	3.5 min per 22 x 74 mm substrate at 10 µm resolution
Autoloader capacity	24 standard 25 x 76 mm glass substrate slides
Autoloader speed	5 seconds load/unload per substrate slide
Autoloader throughput	100 min for 24 substrate slides
Scan area	Full substrate slide area (22 x 74 mm)
Image format	Standard TIFF (16 bit gray scale)
Barcode reader	All formats
Power supply	88 - 264 VAC
Size (L x D x H)	28 x 46 x 37 cm (model 710); 33 x 60 x 42 cm (model 710AL)
Weight	16 Kg (model 710 and 710IR); 27 Kg (model 710AL and 710IRAL)
Class	Class I laser product
Sensitivity	0.05 fluor/µm²
Dynamic range	>10,000-fold
Uniformity	<5% CV
Format	Open platform glass substrate slides (25 x 76 mm)
Computer interface	Ethernet
Image analysis	Highly accurate grid positioning using automatic spot recognition provide accurate quantification and 16-bit exportable TIFF data
Compatible fluorophores:	Cy5.5 (685 nm); Cy5, Alexa 647, Alexa 660 (635 nm); Cy3, Alexa 546, Alexa 555 (532 nm); 785 nm infrared dyes, and custom wavelengths available

microarray_scanner_autofocus
Figure 8. The ArrayIt® InnoScan® 710 microarray scanners use dynamic auto focusing, which greatly reduces background noise and increases signal intensities. This proprietary auto-focusing technology allows the system to adjust to temperature changes, mechanical perturbations and other system changes that would otherwise cause fluctuations in signal and background. The result is highly uniform scanning across the entire chip surface and consistent performance scan after scan.

Quantitation and analysis software is included with every scanner:
Mapix® is a microarray image analysis software application that is both intuitive and easy to use, combining imaging and analysis tools for superior performance.

Highly efficient algorithms provide rapid and effective feature gridding through automatic spot searching and optimal grid alignment.

microarray_grid

Automatic spot segmentation ensures high-quality experiment data by selecting relevant pixels and eliminating unwanted ones.
Gridding performance and quantification process are adapted to the high resolution of the InnoScan 710 (3 µm) and therefore to the size of images generated.
Optimal data visualization and quick learning thanks to its highly interactive commands, with full correlation between displayed data, pictures and plots.
Compatible all types of microarrays made by ex-situ and in-situ techniques.
Reads and analyzes interstitial/staggered/orange packing patterned microarrays manufactured with Arrayit NanoPrint 2 Microarrayers, Agilent and others.

microarray_quantitation_software

Batch processing allows analysis of a large number of microarrays per day to boost productivity (available on Version 3.0.0).
Regular software updates are accessible on line to match evolving needs of customers (updates are free for the 1st year).

Configurable for full or modular automation of:

Scanner control
Configuration saving (scan and analysis parameters)
Bar code reading
Quality control by flagging

Compatible with all industry-standard formats and platforms:

Support GAL files and recordable transcripts in both text and GPR formats.
Images are saved as 16-bit TIFF images with all read parameters and can be copied in JPEG format.
Supports image analysis of 16-bit TIFF files from a variety of other scanners.
Platform-independent and runs on all operating systems (Windows, 32- and 64-bit Linux and Macintosh).

Arrayit-InnoScan-710AL
Figure 9. The ArrayIt® InnoScan® 710AL laser microarray scanner with autoloader provides high resolution, high-speed fluorescence scanning of all standard glass microarrays. The 710AL scans 24 glass substrate slides (25 x 76 mm) in both channels at 10 µm resolution in 100 minutes. The ArrayIt® InnoScan® 710AL laser microarray scanner is the perfect automated solution to high-throughput microarray scanning for research, life sciences and microarray testing.

Technical Assistance

Please contact us if you have any comments, suggestions, or if you need technical assistance. We can be reached at all hours by electronic mail (arrayit@arrayit.com) from Monday-Friday 8:00 AM-8 PM PST. Please remember that we want to hear about your successes!

Troubleshooting Tips

Scanner controller software does not connect with scanner – use MAPIX® to re-connect with scanner.

Scanner software does not operate – make sure software dongle is inserted into the computer USB.

Microarray spots in scanned image have low signal strength – increase PMT and laser settings in software.

Scientific Publications

Click here and here for Arrayit scanner scientific publications.

Ordering Information

Warranty

Arrayit life sciences microarray scanners are sold for research purposes only. Arrayit brand products have been scientifically developed and are sold for research purposes. Extreme care and exact attention should be practiced in the use of the materials described herein. All Arrayit brand products are subject to extensive quality control and are guaranteed to perform as described when used properly. Any performance issues should be reported to Arrayit immediately. Arrayit’s liability is limited to the replacement of the product, or a full refund. Any misuse of this product is the full responsibility of the user, and Arrayit makes no warranty or guarantee under such circumstances. Pricing may vary up to 30% due to costs associated with distribution, import taxes, duties, customs clearance and shipping.

Arrayit InnoScan® MAPIX® Microarray Scanner Software

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